Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is linked to the deregulation of transcription.However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity.We developed an R/Bioconductor package, epihet, to calculate the intra-tumoral

Background: A pituitary abscess is a rare infectious disease in the sellar region, but potentially life-threatening, that can be easily misdiagnosed as a pituitary adenoma because pituitary abscesses and adenomas share many clinical manifestations, such as headaches, visual field Shoe Rack changes, hypopituitarism, and imaging examinations suggesti

In this study, hemispheric climatologies of explosive cyclones (ECs) derived using a set of different cyclone detection and tracking methods (CDTMs) are analysed.The aim is to evaluate trends and regional characteristics of ECs discussing consensus and disagreement among methods.Areas of both hemispheres characterised by relatively frequent presenc

Ultra-low contrast percutaneous coronary intervention (ULCPCI) can be performed electively in advanced chronic kidney disease.Engage guide catheter and advance guidewire into the coronary artery without using contrast.IVUS-guided PCI can reduce the STRESS-FX STRESS FORMULA contrast load.Perform co-registration of distal and proximal radio-opaque ma

Different names have been used for multiple births depending on the number of offspring of which common multiples are 2 and 3, in our case we have 5.They are associated with high rates of complications like: preterm labor, pre eclampsia, low birth weight and significant perinatal mortality and morbidity.Quintuplets occur Sleep rarely making the sur